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This paper studies the role of banks’ money creation in monetary transmission. I develop a monetary-search model in which the demand for the monetary base and the money multiplier are endogenously determined through the banks’ money creation channel. Both the model and data show that short-term policy rates and interest on reserves play distinct roles in monetary transmission. I evaluate the theory by matching it with data, and the calibrated model can account for the evolution of the quantity of reserves, excess reserves, and the money multiplier from 1968 to 2015.